Unit I: Principles of Physiologic Function
Unit II: Sensory and Motor Systems
Unit III: Musculoskeletal and Integumental Physiology
Unit IV: Cardiovascular System
Unit V: Respiratory System
Unit VI: Urinary System
Unit VII: Gastrointestinal System
Unit VIII: Endocrine System
Unit IX: Living and Dying. Cell and Membrane Physiology. Overview ; Cellular environment ; Membrane composition ; Clinical Application: Paroxysmal nocturnal hemoglobinuria ; Diffusion ; Pores, channels and carriers ; Clinical Application: Staphylococcus aureus ; Intercellular communication ; Intracellular signaling ; Chapter Summary ; Study Questions
Membrane Excitability. Overview ; Membrane potentials ; Excitation ; Clinical Application: Hypokalemia and hyperkalemia ; Ion channels ; Channel structure ; Channel types ; Chapter Summary ; Study Questions
Osmosis and Body Fluids. Overview ; Osmosis ; Body fluid compartments ; Clinical Application: Hyponatremia and osmotic demyelination syndrome ; Body fluid pH ; Clinical Application: Electrolytes ; Chapter Summary ; Study Questions
Epithelial and Connective Tissue. Overview ; Epithelia ; Clinical Application: Squamous cell carcinoma ; Clinical Application: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis ; Clinical Application: Connexin gene mutations ; Clinical Application: Pemphigus foliaceus ; Movement across epithelia ; Clinical Application: Oral rehydration therapy ; Connective tissue ; Biologic Sex and Aging: Extracellular matrix changes ; Chapter Summary ; Study Questions
Nervous System Organization. Overview ; Nervous system ; Neurons ; Clinical Application: Polio ; Neurotransmission ; Neuroglia ; Clinical Application: Multiple sclerosis ; Nerves ; Chapter Summary ; Study Questions
Central Nervous System. Overview ; Spinal cord ; Brainstem ; Cerebellum ; Diencephalon ; Telencephalon ; Cerebrospinal fluid ; Biologic Sex and Aging: Central nervous system ; Clinical Application: Bacterial meningitis ; Clinical Application: Lumbar puncture ; Chapter Summary ; Study Questions
Autonomic Nervous System. Overview ; Homeostasis ; Organization ; Neurotransmission ; Effector organs ; Brainstem ; Clinical Application: Autonomic dysfunction ; Hypothalamus ; Limbic system ; Chapter Summary ; Study Questions
Vision. Overview ; Eye structure ; Clinical Application: Glaucoma ; Photoreceptors ; Photosensor ; Photosensory transduction ; Color vision ; Visual processing ; Visual pathways ; Optical properties ; Clinical Application: Refractive disorders ; Chapter Summary ; Study Questions
Hearing and Balance. Overview ; Sound ; Auditory system ; Auditory transduction ; Clinical Application: Congenital hearing loss ; Balance ; Clinical Application: Vestibular dysfunction ; Clinical Application: Caloric reflex testing ; Chapter Summary ; Study Questions
Taste and Smell. Overview ; Taste ; Smell ; Clinical Application: Dysgeusia ; Clinical Application: Anosmia ; Biologic Sex and Aging: Taste and smell ; Chapter Summary ; Study Questions
Motor Control Systems. Overview ; Muscle sensory systems ; Spinal cord reflexes ; Clinical Application: Spinal cord injury ; Higher control centers ; Clinical Application: Motor disorders ; Chapter Summary ; Study Questions
Skeletal Muscle. Overview ; Structure ; Clinical Application: Muscular dystrophy ; Clinical Application: Myasthenia gravis ; Excitation-contraction coupling ; Clinical Application: Rigor mortis ; Mechanics ; Types ; Clinical Application: Trismus ("Lockjaw") ; Biologic Sex and Aging: Skeletal muscle ; Paralysis ; Chapter Summary ; Study Questions
Smooth Muscle. Overview ; Structure ; Excitation : Contraction coupling ; Clinical Application: Irritable bowel syndrome ; Clinical Application: Erectile dysfunction ; Cytoskeletal remodeling ; Types ; Chapter Summary ; Study Questions
Bone. Overview ; Formation ; Clinical Application: Osteogenesis imperfecta ; Clinical Application: Paget disease ; Anatomy and growth ; Remodeling ; Clinical Application: Remodeling disorders ; Biologic Sex and Aging: Bone mass ; Chapter Summary ; Study Questions
Skin. Overview ; Anatomy ; Epidermis ; Clinical Application: Abrasions and burns ; Dermis ; Clinical Application: Triple response ; Hypodermis ; Specialized skin structures ; Clinical Application: Acne ; Cutaneous nerves ; Biologic Sex and Aging: Skin ; Clinical Application: Shingles ; Chapter Summary ; Study Questions
Cardiac Excitation. Overview ; Cardiovascular circuitry ; Cardiac muscle ; Clinical Application: Hypertrophic cardiomyopathy ; Sequencing contractions ; Electrophysiology ; Biologic Sex and Aging: Heart rate ; Electrocardiography ; Clinical Application: Long QT syndrome ; Biologic Sex and Aging: Cardiac dysrhythmias ; Clinical Application: Myocardial infarction ; Chapter Summary ; Study Questions
Cardiac Mechanics. Overview ; Cardiac cycle ; Clinical Application: Heart murmurs ; Biologic Sex and Aging: Cardiac size and function ; Excitation : Contraction coupling ; Cardiac output ; Clinical Application: Cardiac markers ; Clinical Application: Beta-blockers and Calcium-channel blockers ; Energy source ; Cardiac work ; Clinical Application: Hypertensive myocardial hypertrophy ; Chapter Summary ; Study Questions
Blood and the Vasculature. Overview ; Vasculature ; Blood flow determinants ; Hemodynamic Ohm law ; Clinical Application: Polycythemia vera ; Limits of the Poiseuille law ; Clinical Application: Thrombi and anticoagulation therapy ; Biologic Sex and Aging: Arterial compliance ; Exchange between blood and tissues ; Fluid movement ; Clinical Application: Lymphatic filariasis ; Starling equilibrium disturbances ; Clinical Application: Congestive heart failure ; Chapter Summary ; Study Questions
Cardiovascular Regulation. Overview ; Vascular control ; Biologic Sex and Aging: Vascular control ; Arterial pressure control ; Clinical Application: Orthostatic hypotension ; Biologic Sex and Aging: Central control of blood pressure ; Long-term control pathways ; Venous return ; Clinical Application: Coronary artery bypass grafts ; Chapter Summary ; Study Questions
Special Circulations. Overview ; Cerebral circulation ; Clinical Application: Central nervous system ischemic response ; Coronary circulation ; Clinical Application: Angina ; Splanchnic circulation ; Skeletal muscle circulation ; Chapter Summary ; Study Questions
Lung Mechanics. Overview ; Airway anatomy ; Blood supply ; Surface tension and surfactant ; Clinical Application: Infant respiratory distress syndrome ; Mechanics of breathing ; Static lung mechanics ; Biologic Sex and Aging: Lung mechanics ; Lung diseases ; Dynamic lung mechanics ; Clinical Application: Pursed-lipped breathing ; Lung volumes and capacities ; Biologic Sex and Aging: Pulmonary function tests ; Dead space and ventilation ; Clinical Application: Pulmonary function tests ; Chapter Summary ; Study Questions
Gas Exchange. Overview ; Partial pressures ; Pulmonary circulation ; Ventilation / perfusion ratio ; Clinical Application: Pulmonary tuberculosis ; Gas exchange ; Biologic Sex and Aging: Gas exchange ; Chapter Summary ; Study Questions
Blood and Gas Transport. Overview ; Hematopoiesis ; Biologic Sex and Aging: Erythropoiesis and anemia ; Clinical Application: Nutritional anemias ; Erythrocytes ; Clinical Application: Globin gene mutations and hemoglobinopathies ; Oxygen transport ; Carbon dioxide transport ; Biologic Sex and Aging: Fetal hemoglobins ; Acid-base considerations ; Chapter Summary ; Study Questions
Respiratory Regulation. Overview ; Neural control centers ; Chemical control of ventilation ; Clinical Application: Sleep apnea ; Biologic Sex and Aging: Respiratory regulation ; Pulmonary receptor role ; Clinical Application: Cheyne-Stokes breathing ; Respiratory adaptation to environment ; Chapter Summary ; Study Questions
Filtration and Micturition. Overview ; Anatomy ; Clinical Application: Tubulointerstitial disorders ; Filtration ; Regulation ; Clinical Application: Glomerular disease ; Assessing renal function ; Biologic Sex and Aging: Renal function ; Micturition ; Chapter Summary ; Study Questions
Reabsorption and Secretion. Overview ; Principles ; Organic solutes: Reabsorption ; Clinical Application: Diabetes mellitus ; Organic solutes: Secretion ; Clinical Application: Gout ; Urea ; Phosphate and calcium ; Magnesium ; Potassium ; Bicarbonate and hydrogen ions ; Sodium, chloride, and water ; Chapter Summary ; Study Questions
Urine Formation. Overview ; Loop of Henle ; Clinical Application: Loop diuretics ; Early distal tubule ; Clinical Application: Thiazide diuretics ; Distal segments ; Clinical Application: Potassium-sparing diuretics ; Collecting ducts ; Chapter Summary ; Study Questions
Water and Electrolyte Balance. Overview ; Water balance ; Biologic Sex and Aging: Thirst ; Sodium balance ; Clinical Application: Antidiuretic hormone-release disorders ; Clinical Application: Sodium reabsorption and blood pressure ; Potassium balance ; pH balance ; Acid-base disorders ; Biologic Sex and Aging: Renal homeostatic functions ; Chapter Summary ; Study Questions
Principles and Signaling. Overview ; Gastrointestinal layers ; Clinical Application: Microbiome ; Biologic Sex and Aging: Enteric nervous system ; Innervation ; Clinical Application: Chagas disease ; Motility ; Signaling molecules ; Chapter Summary ; Study Questions
Mouth, Esophagus, and Stomach. Overview ; Mouth ; Clinical Application: Sjögren syndrome ; Esophagus ; Clinical Application: Gastroesophageal reflux disease ; Stomach ; Clinical Application: Vomiting ; Clinical Application: Gastric ulcers ; Appetite ; Chapter Summary ; Study Questions
Small and Large Intestines. Overview ; Small intestine ; Clinical Application: Lactose intolerance ; Clinical Application: Hartnup disease ; Large intestine ; Clinical Application: Diarrhea and metabolic acidosis ; Chapter Summary ; Study Questions
Exocrine Pancreas and Liver. Overview ; Exocrine pancreas ; Clinical Application: Cystic fibrosis ; Hepatobiliary system ; Clinical Application: Cholelithiasis ; Nonbiliary liver functions ; Biologic Sex and Aging: Liver function ; Chapter Summary ; Study Questions
Endocrine Pancreas and Liver. Overview ; Glucose homeostasis ; Endocrine pancreas ; Clinical Application: Diabetes mellitus ; Liver ; Clinical Application: Acromegaly ; Clinical Application: Insulin-like growth factor 1 deficiencies ; Chapter Summary ; Study Questions
Adrenal Glands. Overview ; Adrenal cortex: Cortisol ; Clinical Application: Cushing syndrome ; Adrenal cortex: Androgens ; Biologic Sex and Aging: Adrenal androgens ; Clinical Application: Congenital adrenal hyperplasia ; Adrenal cortex: Aldosterone ; Clinical Application: Primary adrenal insufficiency ; Adrenal medulla: Catecholamines ; Clinical Application: Pheochromocytoma ; Chapter Summary ; Study Questions
Thyroid and Parathyroid Glands. Overview ; Thyroid gland: Thyroid hormones ; Clinical Application: Goiter ; Clinical Application: Hashimoto thyroiditis ; Thyroid glad: Calcitonin ; Parathyroid gland: Parathyroid hormone ; Clinical Application: Graves disease ; Clinical Application: Rickets and osteomalacia ; Chapter Summary ; Study Questions
Male and Female Gonads. Overview ; Sex and gender ; Male gonads ; Clinical Application: Primary male hypogonadism ; Female gonads ; Clinical Application: Polycystic ovary syndrome ; Endometrial cycle ; Biologic Sex and Aging: Menopause ; Mammary glands ; Chapter Summary ; Study Questions
Pregnancy and Birth. Overview ; Implantation ; Placenta ; Maternal physiology ; Clinical Application: Preeclampsia ; Fetal physiology ; Parturition ; Clinical Application: Circulatory transition difficulties ; Chapter Summary ; Study Questions
Thermal Stress and Fever. Overview ; Thermoregulation ; Heat production and transfer ; Clinical Application: Malignant hyperthermia ; Clinical aspects ; Biologic Sex and Aging: Thermoregulation ; Chapter Summary ; Study Questions
Exercise and Bed Rest. Overview ; Definitions ; Oxygen uptake and consumption ; Skeletal muscle ; Clinical Application: Creatine kinase ; Motor and autonomic control ; Cardiovascular system ; Respiratory system ; Endocrine system ; Training ; Biologic Sex and Aging: Exercise ; Bed rest ; Chapter Summary ; Study Questions
Systems Failure. Overview ; Aging and death ; Clinical Application: Therapeutic hypothermia ; Shock classifications ; Clinical Application: Sepsis ; Shock stages ; Heart failure ; Respiratory failure ; Kidney failure ; Multiple organ dysfunction syndrome ; Chapter Summary ; Study Questions
Appendix A: Clinical Cases
Appendix B: Normal Physiologic Values
Appendix C: Reference Equations

"Enhanced with new Clinical Cases, new practice questions, and additional animations, Lippincott Illustrated Reviews: Physiology, 3rd Edition, brings physiology clearly into focus, detailing who we are, how we live, and, ultimately, how we die. By first identifying organ function and then showing how cells and tissues are designed to fulfill that function, this engaging resource decodes physiology like no other text or review book. Tailored for ease of use and fast content absorption, the book's straightforward outline format, visionary artwork, clinical applications, and unit review questions help students master the most essential concepts in physiology, making it perfect for classroom learning and preparation for course and board exams. Approachable Lippincott Illustrated Reviews outline format makes critical information easy to access and assimilate. More than 600 annotated, full-color illustrations guide students step by step through complex processes. NEW! Appendix of 15 Clinical Cases trains students to solve common clinical problems by applying what they’ve learned. Clinical case format is ideal for self-directed learning or for use by instructors to guide small-group discussions. NEW! Detailed explanations of the mechanisms underlying GI motility and reflexes, and a new section discussing regulation of appetite. NEW! Expansion of the chapter on exercise to include a consideration of physiologic limits and training effects. UPDATED! Boards-style study questions, with explanations, at the end of each chapter -- including many new to this edition -- test students’ retention and strengthen their exam confidence."

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