TY - BOOK AU - Eric A. Gehrie (Editor) TI - Rossi's principles of transfusion medicine PY - 2022/// CY - Hoboken, NJ, PB - John Wiley & Sons, Inc. KW - Blood Grouping and Crossmatching KW - Blood Transfusion N1 - Cover Title Page Copyright Page Contents List of contributors Preface List of abbreviations About the companion website SECTION I Transfusion medicine from ancient times to the current pandemic CHAPTER 1 Transfusion in the new millennium The first animal transfusion The first animal-to-human transfusion The beginnings of modern transfusion The twentieth century Anticoagulants, the blood bank, and component therapy Transfusion in the age of technology Concern for blood safety Current status Organization of blood services in the United States Organization of blood services outside the United States Disclaimer Key references CHAPTER 2 Disasters and the blood community (including COVID-19) Background Organization for emergency operations Planning for blood and transfusion in disasters Continuity of operations plans Regulatory considerations in disasters National authority Determination of the acceptability of components in available inventory Potential consequences on operations Records management The COVID-19 pandemic and transfusion medicine Key references CHAPTER 3 Responding to regulatory challenges during public health emergencies Connection between public health emergencies and blood transfusion Approach to pandemic management Epidemiologic surveillance Diagnostic testing Containment and mitigation Therapeutics and vaccines Case study of a therapeutic: COVID-19 convalescent plasma Summary Key references SECTION II Blood donation CHAPTER 4 Recruitment and screening of donors and the collection of blood Donor demographics Donor recruitment and retention Theories of donation behavior Donor retention and repeated donations Extraordinary donations following disasters Recipient-specific blood donation Autologous donations Directed donations Exceptional medical need The collection process for blood components for transfusion: screening, informed consent, phlebotomy, collection, and postdonation Donor screening The current DHQ Changes to the current DHQ based on history of MSM Changes to the FDA required deferrals for risk of CJD and vCJD Educational materials and informed consent Method of administration Vital sign measurement Blood collection Whole blood Postdonation care Component separation Apheresis Collection The collection process for source plasma: screening, phlebotomy, choice of product, collection, and testing of source plasma donors Blood collection changes with patient needs Key references CHAPTER 5 Blood donor testing Background Safety of the blood supply Blood component testing ABO typing Rh typing Red blood cell antibody detection ABO antibody titers Direct antiglobulin testing Testing for transmissible diseases N2 - "Prehistoric man left drawings of himself pierced by arrows.1 This means he was as aware of blood as he was of his own limbs. The flint implements he used as tools and weapons distinguished him from other creatures and contributed to the violence of his era. As he hunted food and fought enemies, he observed bleeding and the properties of blood. A cut, received or inflicted, yielded a vivid red color. If the cut was shallow, there was little blood. But if the cut was deep, a red torrent flowing from the stricken victim quickly led to death, with shed blood congealed and darkening in the sun. Fatal hemorrhage was commonplace. Nonetheless, the sight must have been fearful and possibly existential as life flowed red out of the body of an enemy or a wounded animal. 2 It is no wonder, then, that at the dawn of recorded history, blood was already celebrated in religious rites and rituals as a life-giving force ER -