Cover
Title Page
Copyright Page
Contents
List of contributors
Preface
List of abbreviations
About the companion website
SECTION I Transfusion medicine from ancient times to the current pandemic
CHAPTER 1 Transfusion in the new millennium
The first animal transfusion
The first animal-to-human transfusion
The beginnings of modern transfusion
The twentieth century
Anticoagulants, the blood bank, and component therapy
Transfusion in the age of technology
Concern for blood safety
Current status Organization of blood services in the United States
Organization of blood services outside the United States
Disclaimer
Key references
CHAPTER 2 Disasters and the blood community (including COVID-19)
Background
Organization for emergency operations
Planning for blood and transfusion in disasters
Continuity of operations plans
Regulatory considerations in disasters
National authority
Determination of the acceptability of components in available inventory
Potential consequences on operations
Records management
The COVID-19 pandemic and transfusion medicine Key references
CHAPTER 3 Responding to regulatory challenges during public health emergencies
Connection between public health emergencies and blood transfusion
Approach to pandemic management
Epidemiologic surveillance
Diagnostic testing
Containment and mitigation
Therapeutics and vaccines
Case study of a therapeutic: COVID-19 convalescent plasma
Summary
Key references
SECTION II Blood donation
CHAPTER 4 Recruitment and screening of donors and the collection of blood
Donor demographics
Donor recruitment and retention
Theories of donation behavior Donor retention and repeated donations
Extraordinary donations following disasters
Recipient-specific blood donation
Autologous donations
Directed donations
Exceptional medical need
The collection process for blood components for transfusion: screening, informed consent, phlebotomy, collection, and postdonation
Donor screening
The current DHQ
Changes to the current DHQ based on history of MSM
Changes to the FDA required deferrals for risk of CJD and vCJD
Educational materials and informed consent
Method of administration
Vital sign measurement Blood collection
Whole blood
Postdonation care
Component separation
Apheresis Collection
The collection process for source plasma: screening, phlebotomy, choice of product, collection, and testing of source plasma donors
Blood collection changes with patient needs
Key references
CHAPTER 5 Blood donor testing
Background
Safety of the blood supply
Blood component testing
ABO typing
Rh typing
Red blood cell antibody detection
ABO antibody titers
Direct antiglobulin testing
Testing for transmissible diseases

"Prehistoric man left drawings of himself pierced by arrows.1 This means he was as aware of blood as he was of his own limbs. The flint implements he used as tools and weapons distinguished him from other creatures and contributed to the violence of his era. As he hunted food and fought enemies, he observed bleeding and the properties of blood. A cut, received or inflicted, yielded a vivid red color. If the cut was shallow, there was little blood. But if the cut was deep, a red torrent flowing from the stricken victim quickly led to death, with shed blood congealed and darkening in the sun. Fatal hemorrhage was commonplace. Nonetheless, the sight must have been fearful and possibly existential as life flowed red out of the body of an enemy or a wounded animal. 2 It is no wonder, then, that at the dawn of recorded history, blood was already celebrated in religious rites and rituals as a life-giving force

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